How does raloxifene prevent osteoporosis? [Solved] (2022)

How does raloxifene prevent osteoporosis?

Raloxifene is used to help prevent and treat thinning of the bones (osteoporosis) only in postmenopausal women. It works like an estrogen to stop the bone loss that can develop in women after menopause, but it does not increase the bone density as much as daily 0.625 mg doses of conjugated estrogens.... read more ›

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Why is raloxifene used in osteoporosis?

Reason for posting: Raloxifene is used for the treatment and prevention of osteoporosis. It is a selective estrogen-receptor modulator with estrogen-agonist effects on bone and lipid metabolism but not the breasts and uterus.... see more ›

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What is the mechanism of action of raloxifene?

The mechanism of action of raloxifene occurs through binding to estrogen receptors. This binding results in activation of estrogenic pathways (estrogen-agonistic effect) and blockade (estrogen-antagonistic effect) in tissues that express estrogen receptors.... view details ›

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How does raloxifene work in the body?

How Raloxifene works. Raloxifene acts like the female sex hormone oestrogen, although it isn't a hormone. It copies how the oestrogen works and is able to increase the thickness (density) of the bone to prevent and treat bone thinning. To prevent breast cancer raloxifene is able to block the hormone oestrogen.... see details ›

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How do SERMs prevent osteoporosis?

Some SERMs, such as raloxifene and bazedoxifene, have estrogen activity in bone and, therefore, prevent bone loss, improve bone mineral density (BMD), and decrease the risk of vertebral fracture. The use of SERMs for the prevention and treatment of osteoporosis will be discussed here.... see more ›

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How effective is raloxifene for osteoporosis?

The significant 25% reduction in global index (150 fewer events per 10,000 women taking raloxifene for an average of 3.4 years) is compatible with a favorable risk-benefit safety profile when raloxifene is used for osteoporosis treatment in postmenopausal women.... see more ›

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How long can you take raloxifene for osteoporosis?

Abstract. Background: Due to the chronic nature of osteoporosis and the risk of invasive breast cancer, raloxifene 60 mg/day (raloxifene) is intended to be used for long-term treatment (treatment >3 years).... see details ›

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What are the benefits of raloxifene?

Raloxifene is used by women to prevent and treat bone loss (osteoporosis) after menopause. It slows down bone loss and helps to keep bones strong, making them less likely to break. Raloxifene may also lower the chance of getting a certain type of breast cancer (invasive breast cancer) after menopause.... read more ›

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What happens when you stop taking raloxifene?

discontinuation). Patients, who discontinued alendronate therapy experienced an increase in bone turnover. Bone turnover increases were less pronounced in patients taking raloxifene and were absent in those who continued alendronate.... see more ›

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What is the black box warning for raloxifene?

WARNING: Raloxifene may rarely cause serious blood clots, especially in the legs or lungs. Women who have or had blood clots (including in the legs, lungs, or eyes) should not take raloxifene.... view details ›

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How does estrogen affect osteoporosis?

How does estrogen help with osteoporosis? The hormone estrogen regulates bone metabolism. It is essential to bone health because it promotes the activity of osteoblasts, which are the cells that make new bone. When estrogen levels drop — for example, during menopause — a person may lose bone density.... see more ›

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What is the main action of Evista?

Available in many countries worldwide, raloxifene was initially approved by the FDA in December, 1997 under the market name Evista® for the management and prevention of osteoporosis in postmenopausal women and reduction in risk for invasive breast cancer in postmenopausal women with osteoporosis or those who are at ...... continue reading ›

How does raloxifene prevent osteoporosis? [Solved] (2022)

Is raloxifene a bisphosphonate?

The bisphosphonate alendronate and the selective estrogen receptor modulator (SERM) raloxifene are among the most popular antiresorptive agents for the prevention and treatment of postmenopausal osteoporosis6,7.... see details ›

What is the difference between tamoxifen and raloxifene?

Tamoxifen is used mainly to treat hormone receptor-positive breast cancer (breast cancer with cells that have estrogen and/or progesterone receptors on them). Raloxifene is used mostly to prevent and treat osteoporosis (very weak bones) in post-menopausal women.... view details ›

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